“... there was no room for him in the inn.” Lk 2:7b
It’s not uncommon for man to reject what God wills. Mary and Jesus were turned away at the inn by man. And no it would not of mattered if they had known he was God because they still rejected him once he was revealed as God. It’s man’s great flaw to reject or discard what God has promoted. But know that what God calls and ordains man has no authority over. The only way in which man can disrupt what God has called is for man to succumb to man instead of God. What God has called you to God holds you to, and not based on the approval of man but based on his will. And thus he gifts you in every aspect to accomplish such. Gifts are not toys to play with, they are tools to build with. If they are not used in love and obedience, they instead become weapons to fight with. This is what happened in the church of Corinth (1 Cor 12-14). Unfortunately man is highly prone to respond to God’s will according to their preference and wishes, and not Gods.
Man can make many plans, but the Lord’s purpose will prevail (Pro 19:21)